Department of Medical Psychology, VU University Medical Centre, Amsterdam, The Netherlands
Perspective
MEG resting-state network changes are linked to cognitive deterioration in type 1 diabetic patients.
Author(s): Elco Dunkerken*
Objective: For proper cognitive function, the integrity of resting-state
functional brain networks (RSNs) is crucial. Cognitive decline is common in
type 1 diabetes mellitus (T1DM), possibly as a result of changes in RSNs,
which may vary depending on microvascular complication status. Using an
impartial method and a high spatio-temporal resolution functional network,
we therefore tested the hypothesis that functional connectivity in RSNs
differs according to clinical status and correlates with cognition in T1DM
patients.
Methods: We collected resting-state magnetoencephalographic (MEG)
data from 33 healthy participants and 42 T1DM patients with and without
microvascular complications. A new atlas-based beamformer was used to
reconstruct MEG time series at the source level. The phase lag index (PLI)
was used to .. View More»
DOI:
10.35248/2155-6156.1000988
