Bioinformatics and Molecular Biology Unit, Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria
Research Article
Influence of Bambusa vulgaris leaves extract on Endoplasmic Reticulum Stress Induced by Streptozotocin in Wistar Rats.
Author(s): Bolade Victoria Olubodun*, Olusola Olalekan Elekofehinti, Akeem Olalekan Lawal, Idowu Waheed Ajibade,, Bukunmi Akinleye Sarah, Motunrayo Margaret Tayelolu, Faith Oghuansuan Oluwatosin, Olumide Victor Olowolafe and Tosin Samuel Olawumi
Diabetes mellitus is a silent killer that claims about 2 million lives annually. Endoplasmic-reticulum (ER) stress has been linked to type-2 diabetes. This study evaluated the effect of Bambusa vulgaris leaf ethanolic extract (B.V.E.E.) on ER-stress induced by Streptozotocin (STZ) in rats. Rats were divided into six groups and induced with the diabetes using streptozotocin (65 mg/kg) except the control group. Bambusa vulgaris (100, 200 and 400 mg/kg) were administered to the induced rats for twenty-one (21) days. The rats were sacrificed and blood collected for haematology while the liver was harvested for biochemical analysis. The expression of [(activating transcription factor 4 (ATF4), activating transcription factor 6 (ATF6), protein kinase RNA-like endoplasmic reticulum kinase (PERK), tribbles 3 (TRB3), transcription factor C/EBP homologous protein (CHOP), IRE1, interleukin 6 (IL.. View More»
