Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Mali
Research Article
Analgesic and Antiinflammatory Activity of Acacia nilotica (l.) Willd. Ex Delile (mimosaceae), used in the Traditional Management of Liver Deseases in Mali
Author(s): Doumbia Sékou*, Haidara Mahamane, Dembélé Daouda Lassine, Ballo Mahamadou, Dénou Adama, Fofie N’Guessan Bra Yvette and Sanogo Rokia
In Mali, Acacia nilotica is widely used in traditional medicine in the management of many diseases including liver diseases. The objective was to estimate the toxicity and to evaluate the analgesic and anti-inflammatory effects of aqueous (infused) extracts of leafy twigs, stem barks and fruits of A. nilotica. Toxicity was estimated according to OECD guidelines. The analgesic activity of the extracts was evaluated on the pain caused in mice or rats by acetic acid, formalin and hot water. The anti-inflammatory effect was determined on carrageenan edema in the paws of rats. Orally infused at 5000 mg/kg didn’t cause mortality in rats. Infused from all 3 organs demonstrated a significant reduction in pain and inflammation caused. The stem bark infused gave the best analgesic and anti-inflammatory activity in different tests performed. For the stem bark extract, the number of writhin.. View More»
DOI:
10.35248/11.2.1-5
