Clinical Pathology Department, NCI, Cairo University, Cairo, Egypt
Method Article
A study of Egyptian families found no link between CTLA-4 +49 A/G polymorphism and type 1 diabetes susceptibility.
Author(s): Azham Kamele*
Background: One of the most prevalent chronic diseases that affect
children is type 1 diabetes. Transaction between hereditary weakness
and natural variables is remembered to give the central component to the
sickness. Aside from the Significant Histocompatibility locus which is the
fundamental supporter of chance vulnerability, in excess of 40 loci are
perceived. The CTLA-4 is one of these, but the data from the literature are
disputed. Our research sought to determine whether CTLA4 49 A/G served
as a risk factor for the onset of type 1diabetes in a group of Egyptian
families.
Subjects and methods: This is a case-control study with 88 Egyptian
families that have at least one index case younger than 18 years old. The
control group consisted of 369 healthy, unrelated individuals who did not
have a diabetes or au.. View More»
DOI:
10.35248/2155-6156.1000978
