Editorial Office, Surgery: Current Research, Belgium
Perspective
In a Murine Pancreatic Adenocarcinoma Model, Visceral Surgery Significantly Alters the Cellular and Humoral Components of the Anti-Tumor Immune Response
Author(s): Andreas Wilson*
Especially in the early stages of pancreatic tumors, surgery is the most crucial component of multimodal treatment ideas for oncological patients. While the impact of primary tumor excision on immune function has been examined in a number of studies, the effects of visceral surgery unrelated to a primary tumor on the organism that is carrying the tumor and on the primary tumor itself are still not entirely known. We coupled a mouse model of medically induced immune failure with an orthotopically implanted pancreatic cancer (SID). Over the course of 28 days, mortality and overall health, including body weight, were observed. MRI scans were used to monitor tumor growth on days 8 and days 27 after tumor implantation. The numbers of immune cells in the blood and spleen as well as the serum cytokines were measured on day 28. Compared to the control groups, SID causes a substantial worsenin.. View More»
