Division of Endocrinology, Diabetes and Gastroenterology, University of Manchester, Manchester, UK
Research
Continuous Glucose Monitoring Reveals a Novel Association between Duration and Severity of Hypoglycemia and Small Nerve Fiber Injury in Patients with Diabetes
Author(s): Ibrahim Mohammed and Georgios Ponirakis
Background/Aim: Continuous glucose monitoring (CGM) has revealed that glycemic variability (GV) and low time in range (TIR) are associated with albuminuria and retinopathy. We have investigated the relationship between CGM metrics and highly sensitive markers of nerve pathology using corneal confocal microscopy (CCM) in participants with type 1 and type-2 diabetes.
Methods: A total of 40 participants with diabetes and 28 healthy controls underwent quantification of corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL) and inferior whorl length (IWL). Participants with diabetes underwent CGM for 4 consecutive days.
Results: CNBD was significantly lower in patients with high GV compared to low GV median (range) (25.0(19.0-37.5) vs. 38.6(29.2-46.9); P=0.007); in pat.. View More»
DOI:
10.35248/2155-6156.1000943
