Department of Organic Chemistry, University of Yaounde I, Yaoundé, Cameroon
Research
A New Cerebroside Colahetrophylloside A, from Cola heteropylla (Sterculiaceae) and its Antiplamodial activity
Author(s): Ache Roland Ndifor*, Martin M. Noah, Darline Dize, Celine Henoumont, Alex de Théodore Atchade, Fabrice Fekam Boyom and Laurent Sophie
The increase in resistance to the currently available antimalarial drugs is a call for global concern and warrants search for novel therapeutic drugs from either natural, semisynthetic or synthetic sources with improved biological activity. Cameroonian Traditional healers have been using Cola heteropylla for the treatment of malaria in endemic regions. Thus, this study aimed at investigating the phytochemical constituents of leaf extract from Cola heteropylla and screening of their antiplasmodial activity. The methanol leaf extract and its isolates were prepared using standard procedures and their antiplasmodial activity was assessed in vitro against the Pf3D7 and PfDd2 strains of Plasmodium falciparum. The performed isolation afforded one new antiplasmodial cerebroside Colaheterophylloside A, and the previously described oleanolic acid, ursolic acid and methyl ester of Colic acid. Th.. View More»
