Asia-Pacific Institute of Aging Studies, Lingnan University, Tuen Mun, Hong Kong
Research Article
Design, Synthesis and Characterization of Novel Curcumin Derivatives
Author(s): Siukan Law, Chuiman Lo, Jie Han, Fanwen Yang, Albert Wingnang Leung and Chuanshan Xu*
Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.
In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy- 1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%.. View More»
DOI:
10.35248/2329-6836.20.8.367
