Department of Biology, Islamic Azad University, Tehran, Iran
Research Article
Quercetin Reduces Disease Progression and Ameliorates in A Murine Model of Experimental Autoimmune Encephalomyelitis (EAE)
Author(s): Ali Ebrahimi, Kazem Parivar*, Nasim Hayati-e Roodbari and Akram Eidi
Background: It is now known that quercetin, a plant flavonoid, exerts numerous biological roles, such as anti-inflammatory, anti-cancer, antioxidant activity, and it also promotes the differentiation of neuronal precursor cells. Hence, in the present study, we aimed to investigate whether the administration of quercetin is able to impede the progression of experimental autoimmune encephalomyelitis (EAE) in rats and incite neuronal repair in damaged areas. In order to induce EAE, an equal ratio of the spinal cord of guinea pig (as homogenate) and Complete Freund's Adjuvant (CFA) was prepared. Then, 30 rats were assigned to three groups of ES (induced by EAE and treated with normal saline), EQI (induced by EAE and treated with Injectable Quercetin), and EQO (induced by EAE and treated with Quercetin Orally) groups. Treatment started on the day after the onset of the.. View More»
