Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt
Editorial
The connection of polymorphism locations in certain genes with type 1 diabetes in an Egyptian kid sample
Author(s): Abraham Kalfoury*
Background: It has been hypothesized that the major histocompatibility
complex (MHC) genes are the primary genetic factor in the predisposition
to type 1 diabetes mellitus (T1DM). It had also been reported that other
loci outside the MHC contributed to T1DM susceptibility. In this study,
we looked at a sample of Egyptian children to see how some variants of
polymorphic sites in some genes that are linked to T1DM played a role.
Methods and subjects: This study included 60 healthy participants and 60
T1DM patients from Alexandria University Children's Hospital's diabetes
clinic. The method of isopropanol precipitation was used to extract
genomic DNA. Genotyping was performed on cytotoxic T-lymphocyte
antigen-4 (CTLA-4) as well as the vitamin D receptor (VDR), interleukin
10 (IL-10), protein tyrosine phosphatase non.. View More»
DOI:
10.35248/2155-6156.1000981
