Zacharias M Sinakosa and George D Geromichalosb
In current review is described in short the findings indicating that Crocus sativus exerts antithrombotic and antiatherosclerosis effect. Summarily, these findings include the documented antioxidant activity of C. sativus on LDL oxidation leading to the initiation of atherosclerosis, its inhibitory effect on the expression of cell adhesion molecules and the adhesion of leucocytes to endothelial cells. Additionally, C. sativus contributes in the inhibition of platelet aggregation, inhibiting coagulation factor Xa and COX-1 (in vitro and in silico studies). All these activities contribute to the inhibition of the progression of atherosclerosis.
