The relationship between gut microbiota diversity and insulin resistance in diabetes mellitus patients has garnered increasing attention in bioinformatics research. This study aimed to examine the variety of stomach microbiota and its impact on insulin resistance in diabetic individuals. Through highthroughput sequencing of microbial DNA extracted from stomach samples of diabetic patients, we analyzed the diversity and composition of the microbiota. Additionally, we assessed insulin resistance using standardized clinical measures and correlated these with microbiota profiles. Our findings revealed significant alterations in the stomach microbiota diversity in diabetic patients compared to healthy controls, with a notable decrease in richness and evenness. Furthermore, specific microbial taxa were found to be associated with insulin resistance, highlighting potential microbial biomarkers for disease monitoring and therapeutic interventions. This study contributes to our understanding of the complex interplay between gut microbiota and metabolic disorders, shedding light on novel avenues for diabetes management and personalized treatment strategies.
