There has been a lot of research about the human microbes, some detailed investigations of the gastrointestinal microorganisms and its functions, and the highlighting of complex interactions between the gut, the gut micro biome, and the central nervous system. That acquires the involvement of the micro biome in the pathogenesis of various diseases. The gut micro biota is sensitive to internal and environmental influences, we have speculated that among the factors that influence the formation and composition of gut micro biota during life. Micro biome in human system is unequally distributed in the body and includes the aggregate of all microorganisms.