Mahashweta Das, Shipra Banik, Puspita Mandal, Rui Gong, Debajyoti Chakrabarty, Sunit Kumar Medda and Rabindra Nath Das*
Objective: Pregnancy, gestational diabetes and induced hypertension are frequently observed in practice among the pregnant women, but their relationships are not well realized. The article aims to develop the relationship of pregnancy on diabetes, hypertension and some other related parameters.
Methods: The targeted response ‘the number of pregnancies’ is heteroscedastic, which is not stabilized by any suitable transformation. It is modeled herein using joint generalized linear models under both the lognormal and gamma distributions.
Results: It is derived herein that diabetic women (P=0.0053) become pregnant earlier than normal women. Mean pregnancy is positively linked to glucose level (P=0.0013) and age (P<0.0001), while it is negatively linked to their joint interaction effect Glucose*Age (P=0.0003). It is partially positively linked to body mass index (BMI) (P=0.1129) and free of triceps skin-fold thickness (TST) (P=0.2747), while it is negatively linked to their joint interaction effect TST*BMI (P=0.0039), and it is also positively linked to TST*Age (P<0.0001). In addition, mean pregnancy is negatively linked to insulin level (P=0.0170) and diabetes pedigree function (DPF) (P=0.0890). Variance of pregnancy is positively linked to glucose level (P=0.1061) and diastolic blood pressure (DBP) (P=0.0657), while it is negatively linked to their joint effect Glucose*DBP (P=0.0125). Variance of pregnancy is negatively linked to TST (P<0.0001) and positively linked to DPF (P=0.0309), while it is negatively linked to the interaction effect TST*DPF (P=0.0985), and positively linked to DBP*TST (P= 0.0006). In addition, variance of pregnancy is negatively linked to insulin level (P=0.0871), while it is partially positively linked to the interaction effect Insulin*DBP (P=0.1652), but free of BMI (P=0.7468).
Conclusions: It is concluded that mean pregnancy is well related to the diabetic functions such as glucose & insulin levels, diabetes history, DPF, BMI, while pregnancy’s variance is well related to the diabetic functions and hypertension parameter DBP. Diabetes women become pregnant more earlier than normal women.
