This study investigates the impact of surgical intervention for primary hyperparathyroidism (PHPT) on insulin sensitivity in patients with prediabetes. Prediabetic individuals undergoing surgery for PHPT were enrolled, and insulin resistance was assessed before and after the procedure using standardized clinical measures. Results revealed a significant exacerbation of insulin resistance post-surgery, suggesting a potential adverse effect on glucose metabolism. Further research is warranted to elucidate the underlying mechanisms and optimize management strategies for this at-risk population.