Cystic fibrosis (CF) is a complex genetic disorder affecting multiple organ systems, prominently the respiratory and digestive systems. The cooccurrence of diabetes mellitus (DM) and cystic fibrosis-related diabetes (CFRD) further complicates the clinical landscape. This review delves into the intricate pathophysiological mechanisms underlying CF, DM, and CFRD, exploring the synergies and unique challenges presented by their interplay. The genetic mutations causing CF result in impaired chloride transport, leading to viscous secretions and chronic infections. The impact of CFTR dysfunction on pancreatic function and insulin secretion contributes to the development of CFRD. The bidirectional relationship between CF and diabetes exacerbates disease severity and poses challenges in management. Suggestions for comprehensive care include multidisciplinary approaches, personalized therapies, and advancements in CFTR modulator therapies. By understanding the intertwined pathophysiology and offering practical suggestions, this review aims to guide clinicians in optimizing the care of individuals navigating the complex intersection of cystic fibrosis, diabetes, and CFRD
