After heart surgery or percutaneous valve replacement, neurological problems including acute ischemic stroke or postoperative psychosis are common. The purpose of this study was to pinpoint pertinent risk variables. 297 patients who had undergone heart surgery or percutaneous valve replacement had postoperative checks for neurological issues such delirium, stroke, seizures, and hallucinations performed twice daily during three days. In a multivariate model, risk factors for pre- and postoperative complications were assessed. In 43.8% of cases (n=130), there were neurological complications, which included delirium (43.43%, n = 129), stroke (2.7%, n= 8), seizures (1.35%, n=4) and actual hallucinations (3.36%, n=10). Stroke and convulsions are uncommon following heart surgery, however postoperative delirium still happens often. For a challenging postoperative course, a preoperative risk profile with older age, a history of heart failure, and cognitive impairment was discovered. However, it is important to consider the effects of a severe inflammatory reaction.