Metabolic disorders present significant challenges in healthcare due to their complex etiology and limited treatment options. Nanotechnology, coupled with the use of nucleic acid nanoparticles, offers a promising avenue for innovative therapeutic interventions. This review explores the potential of NanoNucleic Treatment for metabolic disorders, focusing on its mechanisms of action, delivery strategies, and therapeutic outcomes. By harnessing the unique properties of nanoparticles and nucleic acids, this approach holds great promise for targeted, personalized therapies that address the underlying molecular pathways of metabolic dysfunction.