For medicolegal investigations, radiological evidence of natural causes of adult death in postmortem imaging is quite valuable. Particularly postmortem computed tomography (PMCT) is being utilised more frequently as a triage tool following external inspection and prior to a thorough autopsy. Radiologists and forensic pathologists frequently handle a variety of fatalities from natural causes. The cardiovascular, neurological, pulmonary, gastrointestinal, and metabolic systems are the most often observed natural causes of mortality. This review offers a summary of the research on organ system-specific postmortem imaging of the most common natural causes of adult mortality