In type 2 diabetic rats with obesity, we looked at whether hyperbaric oxygen improved the skeletal muscle's ability to burn calories through oxidative metabolism and reduced adipocyte hypertrophy. Otsuka, a five-week-old boy In the control and hyperbaric oxygen groups, Long-Evans Tokushima fatty (OLETF) and Long-Evans Tokushima Otsuka (LETO) rats were utilised as diabetic animals and nondiabetic controls, respectively. For three hours each day, animals in the hyperbaric oxygen group were subjected to an atmosphere with a pressure of 1.25 and an oxygen content of 36%. When compared to LETO rats, OLETF rats had significantly higher glucose levels at 27 weeks of age, but OLETF rats exposed to hyperbaric oxygen saw a reduction in this elevation. In the skeletal muscle, the slow-to-fast fibre transition was seen in OLETF rats, but it was suppressed in OLETF animals given hyperbaric oxygen. Hyperbaric oxygen also boosted the muscle fibres' oxidative enzyme activity. Although OLETF rats exposed to hyperbaric oxygen did not exhibit hypertrophied adipocytes, their adipocyte size was bigger than that of LETO rats. Hyperbaric oxygen improves skeletal muscle glucose and lipid metabolism, suggesting that it can prevent glucose rise and adipocyte hypertrophy in diabetic rats with obesity.
