This study investigates the potential of a high-protein diet supplemented with excess leucine to prevent dormancy-induced insulin resistance in women. Dormancy is a common challenge during periods of inactivity, such as bed rest or immobilization, which can lead to metabolic disturbances including insulin resistance. Twenty-five healthy women were subjected to a 10-day bed rest protocol to induce dormancy, during which they were randomized to receive either a high-protein diet enriched with leucine or a control diet. Insulin sensitivity was assessed using oral glucose tolerance tests (OGTT) before and after the bed rest period. Results demonstrate that women receiving the high-protein diet with excess leucine maintained insulin sensitivity compared to those on the control diet (p < 0.05). These findings suggest that dietary interventions targeting protein intake and leucine supplementation may represent a promising strategy to mitigate dormancy-induced insulin resistance in women, potentially improving metabolic health during periods of inactivity
