Therapeutic plants give critical environment administrations, particularly in emerging nations like China, which harbors assorted endemic restorative plant species with significant social and monetary worth. In like manner, understanding the examples and drivers of restorative plant circulation is basic. Notwithstanding, scarcely any examinations have researched the examples and drivers of endemic restorative plants dispersion in China. Here, we connected endemic therapeutic plants circulation with conceivable illustrative factors, i.e., paleoclimate change, contemporary environment, altitudinal reach and ethnic minority human populace size at the prefecture city level in China. Our outcomes show that endemic restorative plants are packed in Southern China, particularly in Southwestern China. Outstanding, both endemic restorative plant species lavishness and the proportion of endemic restorative plant species extravagance are adversely connected with glacial interglacial abnormality in temperature, and emphatically connected with contemporary precipitation and altitudinal reach. Also, we observed that endemic restorative plant species extravagance is emphatically related with ethnic minority populace sizes as well as its proportion to the general populace size. These discoveries propose that the circulation of endemic restorative not entirely set in stone by various drivers. Besides, our discoveries stress that sensational future environment changes and huge anthropogenic exercises in southern China present extraordinary difficulties to the preservation of China's endemic restorative plants.