End Stage Renal Disease (ESRD) is primarily brought on by Diabetic Nephropathy (DN) (ESRD). One of the main pathogenic alterations in DN is glomerulus injury. We used the Gene Expression Omnibus (GEO) database up to December 2020 to identify the gene expression changes in the glomerulus related to DN development. For additional bioinformatics investigation, eleven gene expression datasets pertaining to the human DN glomerulus and its control were retrieved. All expression data was extracted using the R language and Shambhala then cross platform normalised them. By using student's t-test together with false discovery rate and fold change, Differentially Expressed Genes (DEGs) were found. The Database for Annotation, Visualization and Integrated Discovery (DAVID) conducted additional analysis on DEGs to End Stage Renal Disease (ESRD) is primarily brought on by Diabetic Nephropathy (DN) (ESRD). One of the main pathogenic alterations in DN is glomerulus injury. We used the Gene Expression Omnibus (GEO) database up to December 2020 to identify the gene expression changes in the glomerulus related to DN development. For additional bioinformatics investigation, eleven gene expression datasets pertaining to the human DN glomerulus and its control were retrieved. All expression data was extracted using the R language and Shambhala then cross platform normalised them. By using student's t-test together with False Discovery Rate (FDR) (P 0.05) and Fold Change (FC) of 1.5, Differentially Expressed Genes (DEGs) were found. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) conducted additional analysis on DEGs to gain a fresh understanding of DN pathogenesis.
