Hypertension and Type 2 Diabetes (T2D) frequently coexist, creating a synergistic impact on cardiovascular health. This integrative review examines the components contributing to the complex interplay between hypertension and T2D and evaluates the current pharmacotherapeutic strategies employed to manage this dual burden. By synthesizing evidence from diverse sources, this review aims to provide a comprehensive understanding of the multifaceted relationship between hypertension and T2D and inform targeted approaches for effective management. The review scrutinizes the pathophysiological components linking hypertension and T2D, encompassing insulin resistance, endothelial dysfunction, oxidative stress, and inflammatory processes. Additionally, it explores the role of lifestyle factors, genetics, and demographic variables in shaping the hypertensive profile of individuals with T2D. Pharmacotherapy represents a cornerstone in the management of hypertension in individuals with T2D. This review evaluates the efficacy and safety of antihypertensive agents commonly prescribed in this population, including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, diuretics, beta-blockers, and calcium channel blockers. Special attention is given to individualized treatment approaches considering comorbidities, renal function, and potential side effects. The outcomes of this integrative review aim to enhance the understanding of the intricate relationship between hypertension and T2D. By delineating the components contributing to this association and critically appraising pharmacotherapeutic interventions, this review seeks to guide healthcare practitioners in devising personalized and evidence-based strategies for the management of hypertension in individuals with T2D
