Leaves of Plantago lanceolata were traditionally used to treat wounds, burns,
inflammations, fevers, diabetes, and cancer. The present study was carried
out on the Gas Chromatography-Mass Spectrometry (GC-MS) Analysis and
Antitubercular Activities of Leaf Extract of Plantago lanceolata since the plant
was used for wound healing in Ethiopia. The n-hexane extracted powdered
leaves of Plantago lanceolata herb oil were investigated by GC-MS and showed
the presence of 26 compounds. Among these, the major constituents of leaf
oil were 9-Octadecenoic acid (24.20%) and hexadecanoic acid (23.65%).
hence the present work may support the medicinal use of Plantago lanceolata.
The Methyl Isocyanate (MIC) of the crude extracts showed an inhibitory effect
on M. tuberculosis H37Rv was determined at different concentrations of 50
μg/ml, 25 μg/ml, 12.5 μg/ml, 6.25 μg/ml, 3.12 μg/ml, 1.56 μg/ml, and 0.78
μg/ml. Accordingly, the Methyl Isocyanate (MIC) of the pet, the ether extract
was 12.5 μg/ml; while that of CHCl3: MeOH (1:1) and MeOH extract was 6.25
μg/ml and 1.56 μg/ml respectively. It can be concluded that the present study
provided scientific support for the traditional use of Plantago lanceolata leaf
extract for the treatment of tuberculosis.
