Diabetic foot is a debilitating complication of diabetes mellitus characterized by infection, ulceration, or destruction of deep tissues associated with neurological abnormalities and varying degrees of peripheral vascular disease. Despite advances in diabetes care, diabetic foot complications remain a leading cause of non-traumatic lower-extremity amputations worldwide, imposing a significant burden on healthcare systems and patient quality of life. This article explores the multifaceted pathophysiology underlying diabetic foot, emphasizing the interplay of neuropathy, ischemia, and infection. It delves into advancements in diagnostic modalities and therapeutic strategies, including wound care, surgical interventions, and emerging regenerative medicine techniques. By synthesizing recent research, this comprehensive review aims to foster a deeper understanding of diabetic foot management and highlight areas requiring further investigation to enhance patient outcomes and reduce disease burden.
