Diabetes mellitus, a chronic metabolic disorder characterized by high blood glucose levels, poses significant health challenges worldwide. Advances in gene therapy and regenerative medicine offer promising avenues for innovative treatments targeting the underlying pathophysiology of diabetes. This article explores the latest developments in gene therapy approaches, including insulin gene delivery, pancreatic beta-cell regeneration, and stem cell therapies. Additionally, we discuss the role of CRISPR technology in genome editing, highlighting its potential to correct genetic defects associated with diabetes. Furthermore, we examine the challenges and future directions of these therapeutic strategies, emphasizing the importance of translating preclinical findings into clinical practice.
