Syzygium balsameum Wight is a shrubs or trees of Myrtaceae family. The present study reports on the based-on and isolation of a flavonoid 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone from the leaves of Syzygium balsameum and evaluation of antioxidant and cytotoxic property. The compound is characterized by the spectroscopic analysis UV, IR, EIMS, 1H, 13CNMR, Cosy, HMBC and HSQC. The compound 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone is first time isolated from the Syzygium balsameum wight and exhibited good antioxidant and cytotoxic property compare to the extract and the standard.
