Magnetic Resonance Spectroscopic Imaging (MRSI) Study of
International Journal of Collaborative Research on
Internal Medicine & Public Health, 2011 - Vol.
Author: K. B. Ashok *
Midnapore Medical College and Hospital, India
* Corresponding author
Breast cancer is the fifth most common
cause of cancer death worldwide and most serious form of
neoplastic diseases in both developed and developing
countries. Mammography and ultrasound are the most often
used screening methods in breast cancer. Magnetic
Resonance Imaging (MRI) uses the protons in water and
fat to create the image of breast cancer. But recent
studies says neoplastic breast lesions contains elevated
choline concentration (tCho) and altered mean apparent
diffusion coefficient (ADC) which can be used as good
biomarkers to evaluate the cancer stages even follow up
the Neoadjuvent Chemotherapy (NACT).
Aim & Objectives:
To evaluate the relation of age, tCho concentration and
mean ADC with breast cancer.
To estimate the correlation between the factors.
To calculate the main difference between breast cancer
patient before and after menopause.
This was a cross sectional, observational
study done on 14 randomly selected diagnosed stage I
breast cancer patients newly registered in surgery
department of All India Institute of Medical Sciences,
New Delhi, India during 3 months study period.
Intentionally 7 of them were selected to be
postmenopausal and rest 7 premenopausal. Patients with
claustrophobia, serious illness, pacemaker or associated
diseases were excluded. Volunteers were selected by
lottery method after confirmation of absence of the
exclusion criteria in them. All the breast MRS images
were taken only after signing the consent form of being
a volunteer for the study with breast coil. All the
spectroscopic images were analyzed with computer
technologies and SPPS software with the help of
non-parametric statistical tests.
Mean age of patients were 44.85±6.97
where in premenopausal and postmenopausal women it was
40.14±4.59 and 49.57±5.26 respectively. tCho
concentration was high in postmenopausal women
(4.85±2.64 mmol/kg vs 3.72±1.64) where unlike to them
premenopausal women showed higher mean ADC values
(1.02±0.20 vs 0.91±0.09). All together weak correlation
(r= 0.439) found in between the tCho and mean ADC where
age and tCho were weakly correlated among the
premenopausal patients (r=0.440). Among the
postmenopausal women strong correlation found in between
age tCho and mean ADC (r=0.620) and age and mean ADC
It was short term study with very less
population of same category of breast cancer which can
be more appreciated if done in a large population cohort
study design though as a pilot study the aims were
Postmenopausal women show adverse
conditions in breast cancer and using tCho and mean ADC
as biomarkers; the management process becomes easier for
Breast Cancer, MRSI, MRI, Cancer Biomarkers
How to cite this article:
Resonance Spectroscopic Imaging (MRSI) Study of Breast Cancer.
International Journal of Collaborative Research on Internal Medicine & Public
Health. 2011; 3(5):370-376.