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In Vitro Study to determine the effect of zinc on non-heme iron absorption IJCRIMPH articles are provided for free based on an Open Access policy
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International Journal of Collaborative Research on Internal Medicine & Public Health, 2011 - Vol. 3 No. 5

Author: Aswir Abd Rashed *

Nutrition Unit, Institute for Medical Research, Malaysia

* Corresponding author


Abstract:

It has been well documented that bioavailability of iron is influenced by other food constituents. We carried out a kinetic study to look at the effect of zinc on ferric iron uptake in human epithelial Caco-2 TC7 cell-line. Zinc reduced iron uptake in a concentration-dependent manner. Iron uptake was significantly increased in the presence of ascorbic acid in the medium. We also found that zinc significantly increased the main iron transporter Divalent Metal Transporter-1 (DMT1) expression in whole cell and membrane proteins. The evidence from in vitro studies show that zinc suppressed iron uptake by Caco-2 cells and this phenomenon could be reversed by the presence of ascorbic acid in the growth media.

 

Keywords: Iron uptake; Caco-2 TC& cells; Zinc; Ascorbic acid; Ferric iron

How to cite this article:

Abd Rashed A. In Vitro Study to determine the effect of zinc on non-heme iron absorption. International Journal of Collaborative Research on Internal Medicine & Public Health. 2011; 3(5):354-368.

 
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Published Online: 31 May 2011
 
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