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Late ventricular potentials can be predicted from twelve-lead ECG in post-infarction heart failure IJCRIMPH articles are provided for free based on an Open Access policy
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International Journal of Collaborative Research on Internal Medicine & Public Health, 2011 - Vol. 3 No. 1

Author(s): Ioana Mozos (1), Mircea Hancu (1), Corina Serban (1), Anca Tudor (2), Lelia Susan (3)

(1) Department of Pathophysiology, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
(2) Department of Medical Informatics, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
(3) IVth Medical Clinic, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania


Abstract:
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Introduction: Late ventricular potentials (LVP), recorded using signal averaged ECG (SA-ECG), are low-amplitude, high-frequency waveforms, appearing in the terminal part of the QRS complex, and are considered predictors of ventricular arrhythmia and sudden cardiac death.

Hypothesis: SA-ECG parameters can be predicted from 12-lead ECG variables in post-infarction heart failure patients.

Methods: Thirty post infarction heart failure patients were enrolled in our study, and they underwent: 12-lead ECG and SA-ECG.

Results: Among patients with LVP, 75% had a prolonged QTmax (maximal QT interval), 85% a prolonged QTc (heart rate corrected QTmax), 55% QTm (mean QT) ≥ 400ms, 100% QRS (QRS duration) ≥ 100ms, 95% T0e (T wave duration) > 270 ms, 95% Tpe (Tpeak-Tend interval) > 120 ms, 90% Tampl (T wave amplitude) > 0.35 mV. A significant correlation was found between SA-QRS (signal averaged ECG QRS duration) and: QT parameters (p < 0.05), QRS (r = 0.78; p < 0.01), T wave variables (p < 0.01); between RMS40 (the root mean square of the terminal 40 ms of the filtered QRS) and: QTm (p = 0.049), QRS, Toe and between LAS40 (the duration of the low-amplitude signal) and: QTc, Tampl. LVP were significant associated only with QRS (p = 0.034). QRS ≥ 110 ms and T0e ≥ 270 ms are the most sensitive predictors’ of late ventricular potentials and QTm ≥ 400 ms is the most specific.

Conclusion: SA-ECG parameters and the presence of LVP can be predicted from 12-lead ECG variables in post-infarction heart failure patients.

Keywords: Signal averaged electrocardiogram, ventricular late potentials, myocardial infarction, heart failure, QT interval, Tpeak-Tend interval

How to cite this article:

Mozos I, Hancu M, Serban C, Tudor A, Susan L. Late ventricular potentials can be predicted from twelve-lead ECG in post-infarction heart failure. International Journal of Collaborative Research on Internal Medicine & Public Health. 2011; 3:53-63.

 
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Published Online: 20 February 2011
 
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